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DBCO-PEG4-NHS ester

CAS No. 1427004-19-0

DBCO-PEG4-NHS ester( —— )

Catalog No. M23584 CAS No. 1427004-19-0

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DBCO-PEG4-NHS ester
  • Note
    Research use only, not for human use.
  • Brief Description
    DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
  • Description
    DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PEGs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1427004-19-0
  • Formula Weight
    649.69
  • Molecular Formula
    C34H39N3O10
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:79 mg/mL?(121.59 mM;?Need ultrasonic)
  • SMILES
    O=C(CCC(N(C1)c(cccc2)c2C#Cc2c1cccc2)=O)NCCOCCOCCOCCOCCC(ON(C(CC1)=O)C1=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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